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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S2384 | Poliumoside | Reductase | |
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase w... | |||
TN1471 | Cassiaside C | Toralactone 9-O-β-D-gentiobioside | Others , Endogenous Metabolite |
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE). | |||
T7369L | Gemigliptin Tartrate(911637-19-9 free base) | LC15-0444 tartrate | Proteasome , DPP-4 |
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit... | |||
T11877 | LR-90 | Others | |
LR-90, an advanced glycation end product (AGE) inhibitor, is utilized in diabetic animal model research. This compound effectively suppresses inflammatory responses in human monocytes. | |||
T10183 | 6-Methoxytricin | Others | |
6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ... | |||
T12588 | Pyridoxylamine | pyridoxamine | Endogenous Metabolite |
Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs). | |||
T7143 | Alagebrium chloride | ALT711 | Others , Endogenous Metabolite |
Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic | |||
T8583 | Tenilsetam | 3-(2-thienyl)- (9CI),Piperazinone | Others |
Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment. | |||
T2507 | Azeliragon | TTP488 | Beta Amyloid , advanced glycation end products |
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD). | |||
TN2165 | Rubrofusarin gentiobioside | Rubrofusarin-6-O-beta-D-gentiobioside | ERK , NF-κB , TGF-beta/Smad |
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive... | |||
T32098L | Homocarnosine acetate | GABA Receptor , Endogenous Metabolite | |
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition o... | |||
TP1935L1 | RAGE antagonist peptide acetate | Beta Amyloid | |
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents ... | |||
T10619 | Bromelain | Apoptosis , Others | |
Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,... | |||
T39115 | ABR-238901 | TLR | |
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a... | |||
TN1042 | Chebulic acid | Others | |
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t... | |||
T9948 | NecroX-7 | LC-280126,LC28-0126,LC28 0126 | NADPH-oxidase |
NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ... | |||
TN3972 | Epimedokoreanin B | Apoptosis , Others , Antibacterial | |
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-... | |||
T29819 | Alagebrium bromide | ALT-711,ALT 711,ALT711 | |
Alagebrium is a advanced glycation endproducts (AGE) cross-link breaker. | |||
T70059 | ALT-946 HCl | ||
ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. | |||
T68794 | ALT-946 free base | ||
ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. |