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Search Results for " advanced glycation "

20

Compounds

Cat No. Product Name Synonyms Targets
T6S2384 Poliumoside Reductase
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase w...
TN1471 Cassiaside C Toralactone 9-O-β-D-gentiobioside Others , Endogenous Metabolite
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE).
T7369L Gemigliptin Tartrate(911637-19-9 free base) LC15-0444 tartrate Proteasome , DPP-4
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit...
T11877 LR-90 Others
LR-90, an advanced glycation end product (AGE) inhibitor, is utilized in diabetic animal model research. This compound effectively suppresses inflammatory responses in human monocytes.
T10183 6-Methoxytricin Others
6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ...
T12588 Pyridoxylamine pyridoxamine Endogenous Metabolite
Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
T7143 Alagebrium chloride ALT711 Others , Endogenous Metabolite
Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic
T8583 Tenilsetam 3-(2-thienyl)- (9CI),Piperazinone Others
Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.
T2507 Azeliragon TTP488 Beta Amyloid , advanced glycation end products
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).
TN2165 Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside ERK , NF-κB , TGF-beta/Smad
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...
T32098L Homocarnosine acetate GABA Receptor , Endogenous Metabolite
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition o...
TP1935L1 RAGE antagonist peptide acetate Beta Amyloid
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents ...
T10619 Bromelain Apoptosis , Others
Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,...
T39115 ABR-238901 TLR
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a...
TN1042 Chebulic acid Others
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t...
T9948 NecroX-7 LC-280126,LC28-0126,LC28 0126 NADPH-oxidase
NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ...
TN3972 Epimedokoreanin B Apoptosis , Others , Antibacterial
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-...
T29819 Alagebrium bromide ALT-711,ALT 711,ALT711
Alagebrium is a advanced glycation endproducts (AGE) cross-link breaker.
T70059 ALT-946 HCl
ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
T68794 ALT-946 free base
ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
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